Norbert Mehlmer

Group Systems Biology

The focus of my work combines different aspects of systems biology with applied and basic research on biotechnology. This will allow comprehensive insights into complete fermentative processes and enables the identification of bottlenecks in recombinant and natural production hosts. Systems biology is the key for understanding and predicting metabolic pathways by fitting recombinant pathways into cellular processes which are influenced by internal and external stimuli. The comprehensive analysis of metabolic fluxes together with the expression analysis (proteome and transcriptome) allows knowledge-based manipulation of microbial hosts and the design of user-defined microbial production hosts.

Key publications:

Identifying carbohydrate-active enzymes of Cutaneotrichosporon oleaginosus using systems biology, T. Fuchs, F. Melcher, Z. S. Rerop, J. Lorenzen, P. Shaigani, D. Awad, M. Haack, S. A. Prem, M. Masri, N. Mehlmer,* T. Brück,* Microb. Cell Fact. 2021, 20, 205.

A sustainable, high-performance process for the economic production of waste-free microbial oils that can replace plant-based equivalents, M. A. Masri, D. Garbe, N. Mehlmer,* T. Brück,* Energy Environ. Sci. 2019, 12, 2717–2732.

A waste-free, microbial oil centered cyclic bio-refinery approach based on flexible macroalgae biomass, M. A. Masri, W. Jurkowski, P. Shaigani, M. Haack, N. Mehlmer,* T. Brück,* Appl. Energy 2018, 224, 1–12.